PREPARATION AND CHARACTERIZATION OF SOLID DISPERSIONS OF CARVEDILOL WITH POLOXAMER 188
نویسندگان
چکیده
منابع مشابه
Preparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and PVP-K30 as carriers
Objective(s):Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). Materials and Methods: Solid dispersions of CLX:PVP or CLX:PLX were prepared at different r...
متن کاملpreparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and pvp-k30 as carriers
objective(s):solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. the aim of this study was to compare the effect of polyvinylpyrrolidone k30 (pvp) and poloxamer-188 (plx) as carrier in solid dispersion formulations of celecoxib (clx). materials and methods: solid dispersions of clx:pvp or clx:plx were prepared at different r...
متن کاملPreparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and PVP-K30 as carriers
OBJECTIVES Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). MATERIALS AND METHODS Solid dispersions of CLX:PVP or CLX:PLX were prepared at different ra...
متن کاملpreparation and characterization of solid dispersions of carvedilol with pvp k30
solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. the poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. the purpose of the present investigation was to increase the solubility and dissolution rate of carve...
متن کاملPreparation and characterization of solid dispersions of carvedilol with PVP K30
Solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. The poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. The purpose of the present investigation was to increase the solubility and dissolution rate of carve...
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ژورنال
عنوان ژورنال: Journal of the Chilean Chemical Society
سال: 2013
ISSN: 0717-9707
DOI: 10.4067/s0717-97072013000100012